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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 12971344 of 1712 trials
Suspended·Phase 4·Other

Multimodal Analgesia vs. Routine Care Pain Management for Lumbar Spine Fusion Surgery: A Prospective Randomized Study

OrthoCarolina Research Institute, Inc.

Single Level Lumbar Decompression and Fusion Spine Surgery
Suspended·Phase 3·ketamine

Systemic Ketamine for the Improvement of Post-Operative Analgesia at the Alcohol-Dependent Patient

University Hospital, Clermont-Ferrand

Alcoholic PatientCarcinological Surgery ORL
Terminated·N/A·ketamine

Role Of Non-Specific Effects in The Treatment of Depression With Esketamine

Yale University

Depressive Episode
Terminated·Phase 2·ketamine

Ketamine for OUD and Suicidal Ideation in the ED

Brigham and Women's Hospital

Opioid Use DisorderSuicidal Ideation
Terminated·N/A·ketamine

Behavioural Activation Therapy and Esketamine for Resistant Depression

The Royal's Institute of Mental Health Research

Depressive Disorder, Treatment-ResistantDepressive Disorder, MajorBipolar Disorder
Terminated·Phase 4·ketamine

Ketamine-assisted Therapy for Advanced GI Cancer

Brian Anderson, MD

Pancreatic Ductal AdenocarcinomaPain, AcuteGastrointestinal Cancers+1 more
Terminated·Early Phase 1·ketamine

Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI Cancers

University of Utah

Gastrointestinal CancerDepressionAnxiety
Terminated·Phase 2·DMT

Phase 2 Clinical Trial of GH001 in Bipolar II Disorder

GH Research Ireland Limited

Bipolar II Disorder
Terminated·Phase 2·DMT

Phase 2 Clinical Trial of GH001 in Postpartum Depression

GH Research Ireland Limited

Postpartum DepressionPostnatal Depression
Terminated·Phase 1·ketamine

[11C]-(R)-Rolipram to Measure cAMP Signaling Before and After Ketamine

National Institute of Mental Health (NIMH)

Depression
Terminated·Phase 2·ketamine

Repeated Intranasal Esketamine Plus Almond Therapy in Patients With Treatment Resistant Depression

Zylorion Health

Treatment Resistant Major Depressive Disorder
Terminated·Phase 4·ketamine

Ketamine Pilot Study

Meghan Spyres

Rattlesnake Envenomation
Terminated·Phase 1·ketamine

Ketamine Infusion for Rapid Reduction of Suicidality in Pediatrics

University of British Columbia

Suicidal Ideation
Terminated·Phase 4·ketamine

Low-dose KETamine as an Adjunct to MOrphine for Acute Pain in the ED

University of Aarhus

Acute PainOpioid Use
Terminated·Phase 1·ketamine

The Using Postoperative Ketamine and Exploring the Effect on Endometriosis Pain (UPKEEEP) Study

NYU Langone Health

EndometriosisPost Operative Pain
Terminated·Phase 1·ketamine

Ketamine for OUD and Comorbid Depression (OUDCD)

University of Maryland, Baltimore

Opioid Use DisorderDepressive Disorder
Terminated·Phase 2·ketamine

Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous Ketamine

Yale University

Adolescent SuicideAdolescent Depression
Terminated·Phase 2·ketamine

KAP for Depression in Abstinent Opioid Users

Medical University of South Carolina

Opioid Use Disorder, Severe, in Sustained RemissionOpioid Use Disorder, Severe, in Early RemissionMajor Depressive Disorder
Terminated·N/A·ketamine

Effect of Ketamine on Neurological Activity as Measured by Electroencephalogram (EEG)

Entheon Biomedical Corp.

Treatment-resistant Depression
Terminated·Phase 2·MDMA

Study Comparing Two Versus Three Active MDMA-assisted Sessions in U.S. Military Veterans With Chronic PTSD

Resilient Pharmaceuticals

PTSD
Terminated·Phase 4·Other

Vital Capacity in Ultrasound Guided Serratus Plane Block in ED Patients With Multiple Rib Fractures

Antonios Likourezos

Pain
Terminated·Phase 1·psilocybin

Visual Surround Suppression and Perceptual Expectation Under Psilocybin

University of Minnesota

Perception DisturbanceVisual SuppressionPsychedelic Experiences
Terminated·Phase 1·psilocybin

Phase 1b Study in Patients With Short-Lasting Unilateral Neuralgiform Headache Attacks (SUNHA)

Beckley Psytech Limited

Short Lasting Unilateral Neuralgiform Headache Attacks
Terminated·N/A·Other

Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2)-Related Multiple Sclerosis (MS) Vaccination Study

Biogen

Multiple Sclerosis (MS)
Terminated·Early Phase 1·ketamine

Ketamine in Veterans With Gulf War Illness

Baylor College of Medicine

Gulf War Syndrome
Terminated·Phase 1·ketamine

The Effects of Low Dose Ketamine on Cardiovascular Function

University of Texas Southwestern Medical Center

Healthy
Terminated·N/A·ketamine

ESKETamine for FIBromyalgia Treatment

Grand Hôpital de Charleroi

Fibromyalgia
Terminated·N/A·Other

AnaConDa-therapy in COVID-19 Patients

Jeroen Bosch Ziekenhuis

COVID-19SARS CoV-2
Terminated·Early Phase 1·ketamine

PVB vs Ketamine/Lidocaine in Rib Fracture Patients

George Washington University

Rib FracturesRib TraumaRib Fracture Multiple+1 more
Terminated·N/A·psilocybin

PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive Disorder

Usona Institute

Major Depressive Disorder
Terminated·Phase 2·ketamine

Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19

Corewell Health East

COVID-19Acute Respiratory Distress SyndromeSevere Acute Respiratory Syndrome (SARS)+1 more
Terminated·Phase 1·psilocybin

Prophylactic Effects of Psilocybin on Chronic Cluster Headache

Gitte Moos Knudsen

Cluster Headache
Terminated·Phase 3·ketamine

Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery

Case Comprehensive Cancer Center

Postoperative Pain ControlOpioid Consumption
Terminated·Phase 3·ketamine

Initiating Ketamine in Acutely Suicidal Patients in the Emergency Department

Naval Medical Center Camp Lejeune

SuicideSuicide ThreatDepression Severe
Terminated·N/A·Other

Efficacy of Magnetic Resonance-guided High Intensity Focused Ultrasound for the Ablation of Breast Cancer

Kantonsspital Winterthur KSW

Breast Cancer, Invasive Ductal
Terminated·Phase 1·ketamine

Ketamine Interleaved With Electroconvulsive Therapy for Depression

St Patrick's Hospital, Ireland

Depression
Terminated·Phase 4·ketamine

Ketamine + Cognitive Training for Suicidality in the Medical Setting: Pilot

Rebecca Price

Suicide, Attempted
Terminated·Phase 3·ketamine

Intranasal Ketamine for Pain Control in Patients with Sickle Cell Disease and Vaso-occlusive Episode (VOE) in the PED

Abigail Nixon

Sickle Cell DiseaseVaso-Occlusive Pain Episode in Sickle Cell DiseaseVaso-occlusive Crisis+3 more
Terminated·Phase 2·ketamine

Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery

Jacques E. Chelly

Opioid DependenceChronic Pain
Terminated·Phase 4·ketamine

Sub-Dissociative Ketamine and Fentanyl to Treat Moderate to Severe Pain

Mercy Health Ohio

Pain, Acute
Terminated·Phase 4·ketamine

Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures

University of Alabama at Birmingham

TraumaFractures, ClosedChildren, Only+2 more
Terminated·Phase 4·Other

Avoiding Neuromuscular Blockers to Reduce Complications

Beth Israel Deaconess Medical Center

Respiratory FailureRespiratory InfectionAspiration Pneumonia+3 more
Terminated·Phase 2·ketamine

Ketamine for Severe Adolescent Depression: Intermediate-term Safety and Efficacy

Yale University

Major Depressive Disorder
Terminated·Phase 1·ketamine

The Role of HNKs in the Antidepressant Effect of Ketamine

Columbia University

Major Depressive Disorder
Terminated·Phase 4·ketamine

Ketamine for Pain in the Emergency Department

Hackensack Meridian Health

Acute Pain
Terminated·Phase 1·psilocybin

Effects of Psilocybin in Concussion Headache

Yale University

Post-Traumatic Headache
Terminated·Phase 2·ketamine

Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression

The University of Texas Health Science Center, Houston

Post Partum Depression
Terminated·Phase 1·Other

Fecal Microbiota Transplantation (FMT) of FMP30 in Relapsing-Remitting Multiple Sclerosis

Jeffrey Gelfand

Relapsing Remitting Multiple Sclerosis
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.