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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 481528 of 1728 trials
Completed·Phase 2·ketamine

Ketamine for Reduction of Alcoholic Relapse

University College, London

Primary Alcohol Use Disorder
Completed·Phase 1·ketamine

A Study to Assess the pharmacoMRI Effects of AUT00206 in Healthy Males

Autifony Therapeutics Limited

Schizophrenia
Completed·Phase 3·DMT

A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)

Hoffmann-La Roche

Multiple Sclerosis, Relapsing-Remitting
Completed·Phase 2·ketamine

Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease

University Hospital, Lille

Depression
Completed·Phase 4·ketamine

Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency Department

Alameda Health System

Pain
Completed·N/A·Other

Neurocognitive Features of Patients With Treatment-Resistant Depression

Massachusetts General Hospital

Treatment Resistant Depression
Completed·N/A·Other

Impact of Pregabalin in Chronic Users vs. a Perioperative Limited Prescription on Oxycodone Requirement

Christophe Aveline, MD

Postoperative PainNeuropathic Pain
Completed·Phase 1·ketamine

Double-Blind Trial of Ketamine Therapy Plus or Minus Naltrexone in Treatment Resistant Depression (TRD)

Stanford University

Depression
Completed·N/A·ketamine

The Effect of Ketamine on the WAVCNS Index During General Anesthesia: A Feasibility Study

Fraser Health

Anesthesia
Completed·Phase 1·ketamine

Pharmacokinetic, Safety, and Tolerability Study of Intranasally Administered Esketamine in Elderly Japanese, and Healthy Younger Adult Japanese Subjects

Janssen Research & Development, LLC

Healthy
Completed·Phase 4·ketamine

IN Ketamine Vs IN Midazolam and Fentanyl for Abscess I&D

University of Tennessee

AbscessPain
Completed·Phase 1·MDMA

MDMA-Assisted Cognitive-Behavioral Conjoint Therapy (CBCT) in Dyads in Which 1 Member Has Chronic PTSD

Resilient Pharmaceuticals

Posttraumatic Stress Disorder
Completed·Phase 3·ketamine

Neuroprotection During Open Heart Surgery

ghada fouad

Open Heart Surgery
Completed·Phase 1·ketamine

A Study to Evaluate the Effects of Esketamine on Cardiac Repolarization in Healthy Participants

Janssen Research & Development, LLC

Healthy
Completed·N/A·ketamine

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Vanderbilt University

Postoperative Nausea and Vomiting
Completed·N/A·Other

Evaluation of Spine Surgery Analgesic Pathway

The Cleveland Clinic

Posterior Spine Surgery
Completed·Phase 4·ketamine

Methadone and Ketamine for Spinal Surgery

Endeavor Health

Pain
Completed·Phase 3·ketamine

A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant Depression

Janssen Research & Development, LLC

Depressive Disorder, Treatment-Resistant
Completed·Phase 4·ketamine

Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial

University of Texas Southwestern Medical Center

Cardiopulmonary ArrestRespiratory Arrest
Completed·Phase 1·Other

Effect of Stimulant Drugs on Social Perception

University of Chicago

HealthyMDMA ('Ecstasy')
Completed·Phase 1·ketamine

Dexmedetomidine and Ketamine in MRI

Children's Hospital Medical Center, Cincinnati

Magnetic Resonance Imaging
Completed·Phase 2·ketamine

Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisis

UCSF Benioff Children's Hospital Oakland

Sickle Cell DiseaseVaso-Occlusive Crisis
Completed·Phase 4·ketamine

Sedation Methods During Cataract Surgery

Wake Forest University Health Sciences

PhacoemulsificationCataract
Completed·N/A·Other

Preventative Delirium Protocol in Elderly Patients

Rush University Medical Center

Delirium
Completed·Phase 3·ketamine

"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"

Brooke Army Medical Center

HeadacheIntranasal Ketamine
Completed·Phase 2·ketamine

Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder

VA Connecticut Healthcare System

Major Depressive DisorderAlcohol Use Disorder
Completed·Phase 2·ketamine

CAP-Ketamine for Antidepressant Resistant PTSD

VA Office of Research and Development

PTSDPosttraumatic Stress Disorder
Completed·N/A·ketamine

Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia

Washington University School of Medicine

DepressionDeliriumSeizures+1 more
Completed·Phase 4·ketamine

Clinical Trial to Examine Individual Pain Tolerance in the Use of Two Anesthetic Techniques to Perform Saturation Prostate Biopsy

Complexo Hospitalario Universitario de A Coruña

Prostatic Cancer
Completed·Phase 4·ketamine

Geriatric Ketamine for Pain Management Study

Antonios Likourezos

Pain
Completed·Phase 3·ketamine

Pain Reduction With Intranasal Medications for Extremity Injuries

Children's Hospital Medical Center, Cincinnati

PainTraumatic Limb Injury
Completed·Phase 1·ketamine

Crossover Study to Evaluate the Abuse Potential of Intranasal Esketamine Compared to Racemic Intravenous Ketamine in Nondependent, Recreational Drug Users

Janssen Research & Development, LLC

Drug Abuse
Completed·Phase 4·ketamine

The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine

University Medical Center of Southern Nevada

Headache
Completed·N/A·LSD

Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.

St. Olavs Hospital

Depressive DisorderDepressive Disorder, Major
Completed·N/A·ketamine

Ketamine Anesthesia for Improvement of Depression in ECT

VA Puget Sound Health Care System

Major Depressive Disorder
Completed·Phase 4·ketamine

Ketamine for Depression: An MRI Study

Massachusetts General Hospital

DepressionAnxious DepressionMajor Depressive Disorder
Completed·Phase 1·ketamine

A Mass Balance Study With a Microtracer Dose of 14C-esketamine in Healthy Male Participants

Janssen Research & Development, LLC

Healthy
Completed·Phase 2·ketamine

Examining the Impact of Sirolimus on Ketamine's Antidepressant Effects

Yale University

Depression
Completed·Phase 1·ketamine

Pharmacokinetic, Safety, and Tolerability Study of Intranasally Administered Esketamine in Healthy Han Chinese, Korean, Japanese, and Caucasian Participants and the Effects of Rifampin on the Pharmacokinetics of Intranasally Administered Esketamine

Janssen Research & Development, LLC

Healthy
Completed·Phase 3·DMT

A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)

Genentech, Inc.

Multiple Sclerosis, Relapsing-Remitting
Completed·N/A·ketamine

Ketamine for Acute Migraine in the Emergency Department

Carilion Clinic

Headache
Completed·Phase 2·ketamine

Ketamine Infusion in Neurologic Deficit

Unity Health Toronto

Subarachnoid Hemorrhage
Completed·Phase 4·ketamine

The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)

University of Turku

AnesthesiaUnconsciousness
Completed·Early Phase 1·ketamine

Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression.

Sunnybrook Health Sciences Centre

Major Depressive DisorderBipolar I DisorderBipolar II Disorder+2 more
Completed·Phase 3·ketamine

Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Bone Fractures
Completed·Phase 1·ketamine

Study of Intranasal Ketamine for Social Impairment in Autism Spectrum Disorder

Children's Hospital Medical Center, Cincinnati

Autism Spectrum Disorder
Completed·N/A·Other

Participants Preferences to Disease Modifying Agents in Relapsing Remitting Multiple Sclerosis Condition

Hoffmann-La Roche

Multiple Sclerosis, Relapsing-Remitting
Completed·Phase 1·ketamine

A Study to Assess the Effects of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine

Janssen Research & Development, LLC

Renal ImpairmentHealthy
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.