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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 337384 of 1728 trials
Completed·Phase 2·ketamine

Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus

New York State Psychiatric Institute

Tinnitus
Completed·Phase 1·psilocybin

Effects of Psilocybin in Anorexia Nervosa

Johns Hopkins University

Anorexia Nervosa
Completed·Phase 4·ketamine

Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery

Stanford University

Major Depressive DisorderSurgeryOrthopedic Disorder
Completed·Early Phase 1·ketamine

The PATHFINDER Study: A Feasibility Trial

Beth Israel Deaconess Medical Center

Coronary Artery DiseaseDelirium
Completed·N/A·ketamine

Stanford Regulating Circuits of the Brain Study- Ketamine

Stanford University

Healthy
Completed·Phase 2·ketamine

Effect of Ketamine on Laboratory-induced Stress in Healthy Subjects

Icahn School of Medicine at Mount Sinai

Healthy Volunteers
Completed·Early Phase 1·MDMA

Effects of Drugs on Responses to Brain and Emotional Processes

University of Chicago

Autism Spectrum DisorderHealthy
Completed·Phase 2·ketamine

A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients

Arlyne Thung

Adenoid Hypertrophy
Completed·Phase 4·ketamine

Use of Ketamine for Conscious Sedation in Flexible Bronchoscopy

Brooke Army Medical Center

Conscious SedationPatient SatisfactionKetamine
Completed·Phase 1·LSD

Stem Cell Gene Therapy for Cystinosis

University of California, San Diego

Lysosomal Storage DiseasesCystinosis
Completed·Phase 1·psilocybin

Effects of SERT Inhibition on the Subjective Response to Psilocybin in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 2·ketamine

Biomarkers of Response to Ketamine in Depression: MRI and Blood Assays Before and After Open Label Intranasal Ketamine

Dan Iosifescu

Depressive Disorder, Treatment-Resistant
Completed·Phase 4·ketamine

Effects of Ketamine on Mentalizing and Metacognition in Healthy Volunteers

University Hospital, Bonn

Ketamine-Induced Psychotic DisorderSocial CognitionTheory of Mind
Completed·Phase 1·ketamine

The Effects of Sedatives on Tobacco Use Disorder

Wake Forest University Health Sciences

Tobacco Use Disorder
Completed·N/A·Other

Comparison of Two Sedation Versus Placebo Techniques During Cataract Surgery Under Local Anesthesia

University of Liege

SedationCataract
Completed·N/A·ketamine

Impact of Pre-Sedation Virtual Reality Game on Post-Discharge Negative Behaviors in the Pediatric Emergency Department

Medical College of Wisconsin

Behavior, ChildAnxiety
Completed·Phase 4·ketamine

Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute Pain in the Pediatric ED

Antonios Likourezos

Pain
Completed·N/A·ketamine

Ketamine Infusion Therapy for the Treatment of PTSD in Paramedics

Klarisana Physician Services PLLC

Stress Disorders, Post-TraumaticAnxiety Disorders
Completed·Phase 1·Other

Mood Effects of Serotonin Agonists Extended

University of Chicago

Healthy
Completed·Phase 4·ketamine

Nebulized Sub-dissociative Dose Ketamine for Treating Pain

Antonios Likourezos

Pain
Completed·N/A·DMT

Prospective Stratification of Infectious Risks in Multiple Sclerosis

University Hospital, Basel, Switzerland

Multiple Sclerosis
Completed·Phase 1·ketamine

Ketamine and Prolonged Exposure in PTSD

Minneapolis Veterans Affairs Medical Center

Post-traumatic Stress Disorder
Completed·N/A·ketamine

Efficacy and Safety of Continuous Infusion of Ketamine in Pediatric Intensive Care Unit (KISS Study)

Azienda Ospedaliera di Padova

AnalgesiaKetamine ToxicityBronchospasm+1 more
Completed·N/A·ketamine

Spontaneous and Oxytocin-induced Contractility After Exposure to Intravenous Anesthetic Agents: an In-vitro Study in Human Myometrium

Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Postpartum Hemorrhage
Completed·Phase 2·ketamine

Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Bipolar Depression

Celon Pharma SA

Bipolar Depression
Completed·Early Phase 1·psilocybin

Direct Comparison of Altered States of Consciousness Induced by LSD and Psilocybin

University Hospital, Basel, Switzerland

Healthy
Completed·Early Phase 1·ketamine

Ketamine for Refractory Chronic Migraine: a Pilot Study

Thomas Jefferson University

Migraine Headache With Intractable Migraine
Completed·Phase 1·DMT

Safety of GH001 in Healthy Volunteers

GH Research Ireland Limited

Healthy Volunteers
Completed·Phase 2·ketamine

A Study to Evaluate Ketamine for the Treatment of Rett Syndrome

Rett Syndrome Research Trust

Rett Syndrome
Completed·Phase 2·psilocybin

Clinical, Neurocognitive, and Emotional Effects of Psilocybin in Depressed Patients - Proof of Concept

University of Zurich

Depressive Disorder, Major
Completed·N/A·Other

Impact of Opioid Free Anesthesia on Outcome After Hip Arthroplasty by Direct Anterior Approach.

AZ Sint-Jan AV

Hip Arthropathy
Completed·Phase 2·psilocybin

The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression

COMPASS Pathways

Treatment Resistant Depression
Completed·Phase 2·ketamine

Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Depression

Celon Pharma SA

Major Depressive Disorder
Completed·Phase 1·ketamine

A Study to Evaluate Central Nervous System (CNS) Pharmacodynamic Activity of TAK-653 in Healthy Participants Using Transcranial Magnetic Stimulation (TMS)

Neurocrine Biosciences

Healthy Volunteers
Completed·Phase 2·ketamine

Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression

Novartis Pharmaceuticals

Depressive Disorder, Treatment-Resistant
Completed·N/A·ketamine

The Anti-inflammatory Effect of Anesthetics in Abdominal Surgery

University Hospital Dubrava

Colorectal Cancer
Completed·Phase 3·ketamine

Lamotrigine in Reducing Psychologic Side-Effect of Perioperative Ketamine

The Cleveland Clinic

Reducing Psychological Side Effects of Ketamine
Completed·Phase 4·Other

Multimodal Versus Opioid aNalgesia in carDiAc Surgery

University Hospital, Ghent

Postoperative PainPostoperative Delirium
Completed·Phase 2·psilocybin

Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative Mechanisms

Imperial College London

Depressive Disorder, Major
Completed·Phase 1·psilocybin

Psilocybin for Treatment of Obsessive Compulsive Disorder

University of Arizona

Obsessive-compulsive Disorder (OCD)
Completed·N/A·Other

Opioid Free Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypass

Centre Hospitalier Universitaire Dijon

Opioid Free AnaesthesiaOpioid Anaesthesia
Completed·Phase 1·ketamine

A Study to Assess Electrophysiology, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of SAGE-718 Using Ketamine Challenge in Healthy Subjects

Supernus Pharmaceuticals, Inc.

Healthy Volunteer
Completed·Phase 1·ketamine

A Study to Investigate the Different Modes of (S) Ketamine Administration in Healthy Participants

Janssen Research & Development, LLC

Healthy
Completed·Phase 1·ketamine

Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial

Yale University

Depressive Disorder, MajorPost Traumatic Stress DisorderBipolar Disorder
Completed·N/A·Other

Personality Disorders and Substance Use Disorders in a Sexual Context in the Man Having Sex With Other Men Population

Hospices Civils de Lyon

Substance Use Disorders
Completed·Phase 3·MDMA

A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP1)

Resilient Pharmaceuticals

Posttraumatic Stress Disorder
Completed·Phase 3·MDMA

Epigenetics and MDMA-Assisted Psychotherapy for PTSD

University of Southern California

PTSD
Completed·Phase 1·psilocybin

Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.

Yale University

Obsessive-Compulsive Disorder
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.