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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 97144 of 1728 trials
Completed·Phase 1·DMT

Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects (DMT BDR-Study)

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 2·Other

Safety, Tolerability, Analgesic Effect, and Feasibility of Intranasal CT001 in Pediatric Patients

Cessatech A/S

Pain
Completed·N/A·Other

Comparison of Total Intravenous Anesthesia and Inhalational Anesthesia in Opioid-Free Anesthesia for Bariatric Surgery: A Randomized Controlled Trial

Jagiellonian University

Analgesics, OpioidAnesthesia; Adverse Effect
Completed·N/A·ketamine

Opioid-based Versus Opioid-free Endotracheal Intubation

Aretaieion University Hospital

AnesthesiaAnesthesia IntubationOpioid Use+2 more
Completed·N/A·ketamine

Phenomenological Explorations of the Esketamine-Induced Transient Dissociative State

Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

Depressive Disorder
Completed·Phase 2·ketamine

A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive Disorder

Clexio Biosciences Ltd.

Adjunctive Treatment of Major Depressive Disorder (MDD)
Completed·N/A·LSD

LSD-Perceptual-Choice-Study

University Hospital, Basel, Switzerland

LSD Reaction
Completed·N/A·psilocybin

Psilocybin in Alcohol Use Disorder With Comorbid Depression

Centre Hospitalier Universitaire de Nīmes

Alcohol-Related DisordersDepressive DisorderAddiction
Completed·Phase 1·LSD

Effect of Ketanserin, Olanzapine, and Lorazepam After LSD Administration on the Acute Response to LSD in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 1·ayahuasca

Molecular Imaging Study of Harmine/DMT: a Basic Research Approach

Insel Gruppe AG, University Hospital Bern

Neuropharmacological Investigation of Ayahuasca Constituents DMT and Harmine
Completed·Early Phase 1·ketamine

Ketamine for MS Fatigue

Alta Bates Summit Medical Center

Multiple Sclerosis
Completed·N/A·ketamine

Sustained Ketamine Effectiveness for Suicidal Ideation

University Hospital, Montpellier

Depression - Major Depressive DisorderSuicide
Completed·Phase 1·MDMA

Acute Effects of 3,4-methylenedioxymethamphetamine (MDMA) With and Without a Booster Dose

University Hospital, Basel, Switzerland

Healthy
Completed·N/A·Other

Reducing Postoperative Opioids in Patients Undergoing Laparoscopic Hiatal Hernia

Endeavor Health

Hiatal Hernia
Completed·Phase 1·psilocybin

Consciousness, Psilocybin, and Well-Being

University of Wisconsin, Madison

HealthyPsychedelic ExperiencesSleep
Completed·Phase 2·psilocybin

Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder

University of Chicago

Borderline Personality DisorderMajor Depressive Disorder
Completed·Phase 3·Other

COnventional Vs. Optimised PERiprocedural Analgosedation Vs. Total IntraVEnous Anaesthesia for Pulsed-Field Ablation (COOPERATIVE-PFA)

Charles University, Czech Republic

Atrial Fibrillation
Completed·Phase 1·psilocybin

Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy Humans

University of Zurich

Healthy
Completed·N/A·ketamine

Standardised Drug Provocation Testing in Perioperative Hypersensitivity

University Hospital, Antwerp

Allergic ReactionHypersensitivityPerioperative Complication+4 more
Completed·Phase 4·ketamine

Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial

Unity Health Toronto

Neuropathic Pain
Completed·N/A·ketamine

Tapping in Together: A Pilot Study on Group Acupuncture for Ketamine Experience Integration

Academy of Oriental Medicine Austin

Acupuncture
Completed·Phase 3·MDMA

MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy for PTSD

Dr. Leslie Morland

PTSDRelational Problems
Completed·Phase 1·ketamine

KET-RO Plus RO DBT for Treatment Resistant Depression

Washington University School of Medicine

Treatment Resistant Depression
Completed·N/A·ketamine

Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery

Hospital dos Lusíadas

Morbid ObesityPostoperative PainOpioid Free Anesthesia+1 more
Completed·Phase 1·MDMA

Group MDMA-therapy for Veterans With PTSD

Portland VA Research Foundation, Inc

PTSD
Completed·Phase 2·psilocybin

Open-label Study to Assess the Safety and Efficacy of Psilocybin With Psychotherapy in Adult Participants With Fibromyalgia

Kevin Boehnke

Fibromyalgia
Completed·Phase 1·ketamine

Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)

Grace Lim, MD, MS

Pain, PostoperativeDepression, Postpartum
Completed·Phase 2·psilocybin

Psilocybin-assisted Therapy for Treatment of Alcohol Use Disorder

Anders Fink-Jensen, MD, DMSci

Alcohol Use Disorder
Completed·Phase 1·psilocybin

Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·N/A·Other

Anesthesia Depth During Opioid Free Anesthesia

Region Halland

Opioid-free AnesthesiaAnesthesia Depth Monitoring
Completed·Early Phase 1·MDMA

Prosocial Effects of MDMA

University of Chicago

MDMA ('Ecstasy')Social Interaction
Completed·Phase 2·psilocybin

Microdosing Psychedelics to Improve Mood

Rotem Petranker

Major Depressive Disorder
Completed·N/A·DMT

A Study to Describe the Switching From a First- or Second-line Disease Modifying Therapy (DMT) to Ozanimod in Participants With Relapsing Remitting Multiple Sclerosis (RRMS)

Bristol-Myers Squibb

Multiple Sclerosis, Relapsing-Remitting
Completed·N/A·ketamine

Brain Network Dynamics of Depression During Esketamine Treatment

University of North Carolina, Chapel Hill

Depressive Disorder, Major
Completed·Phase 2·psilocybin

Does Psilocybin Require Psychedelic Effects to Treat Depression?

Centre for Addiction and Mental Health

Treatment-resistant Depression
Completed·Phase 1·psilocybin

Psilocybin-assisted CBT for Depression

University of California, Los Angeles

Major Depressive Disorder
Completed·Phase 1·psilocybin

Psilocybin-Assisted Therapy for the Treatment of Cancer-Related Anxiety in Patients With Metastatic Cancer

University of Washington

Hematopoietic and Lymphatic System NeoplasmMetastatic Malignant Solid Neoplasm
Completed·N/A·ketamine

The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric Surgery

Tiva Group

Pharmacological ActionPost Operative PainOpioid Use+2 more
Completed·Phase 2·DMT

A Trial of GH001 in Patients With Treatment-resistant Depression

GH Research Ireland Limited

Treatment-resistant Depression
Completed·N/A·ketamine

Lidocaine and Ketamine Levels in Plasma After Simultaneous Lidocaine/Ketamine Infusions

University Hospital, Basel, Switzerland

Chronic Pain
Completed·Phase 1·DMT

Dose-finding Study for the Combination of DMT and Harmine in Healthy Subjects

Reconnect Labs

Healthy
Completed·Early Phase 1·ketamine

Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder

Medical University of South Carolina

Tobacco UseSmoking CessationNicotine Dependence
Completed·N/A·ketamine

Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression

Medical University of Gdansk

Treatment-Resistant DepressionMajor Depressive Disorder
Completed·N/A·ketamine

Effect of Ketamine Infusion on BIS Values

University of Padova

Anesthesia Brain MonitoringKetamine
Completed·N/A·ketamine

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

Beth Israel Deaconess Medical Center

Postoperative DeliriumHemodynamic InstabilityPain+1 more
Completed·Early Phase 1·ayahuasca

Mindfulness and Psychedelics

Milan Scheidegger

Healthy Participants
Completed·N/A·DMT

Real-World Persistence and Adherence of Ofatumumab Compared to Self-Injectable and Oral DMTs in Patients With Multiple Sclerosis

Novartis

Multiple Sclerosis
Completed·Early Phase 1·ketamine

The Effects of Sedatives on Tobacco Use Disorder Version 2

Wake Forest University Health Sciences

Tobacco Smoking
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.