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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 4996 of 1748 trials
Active, Not Recruiting·N/A·ibogaine

Trifecta Research Study

Axial Therapeutic Research

PTSD - Post Traumatic Stress DisorderCognitive DysfunctionBrain Injury+2 more
Active, Not Recruiting·Phase 1·psilocybin

Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder

Portland VA Research Foundation, Inc

Amphetamine-Related Disorders
Active, Not Recruiting·Phase 1·psilocybin

Comparing the Effects of Psilocin and Psilocybin in Healthy Adults

University of California, San Francisco

Healthy
Active, Not Recruiting·Phase 4·ketamine

Ketamine-Assisted Mindfulness-Based Cognitive Therapy for Depression: A Pilot Study

Ohio State University

Major Depressive Disorder
Active, Not Recruiting·Phase 4·DMT

A Multicenter Study of Continued Current Therapy vs Transition to Ofatumumab After Neurofilament (NfL) Elevation

Novartis Pharmaceuticals

Relapsing-Remitting Multiple Sclerosis
Active, Not Recruiting·Phase 4·ketamine

Ketamine and Kidney Injury in Cardiac Surgery

Mayo Clinic

Cardiac Surgery
Active, Not Recruiting·N/A·Other

Covid-19 Vaccine Immune Response in Multiple Sclerosis

University Hospitals of North Midlands NHS Trust

Multiple Sclerosis
Active, Not Recruiting·Phase 2·psilocybin

Psilocybin Therapy for Depression in Bipolar II Disorder

University of California, San Francisco

Bipolar II Disorder
Active, Not Recruiting·Phase 3·ketamine

Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain

NYU Langone Health

Chronic Postsurgical Pain
Active, Not Recruiting·N/A·ibogaine

Pre-post Evaluation of the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans With Repeated Blast Exposure

Stanford University

Blast or Combat ExposureHead Injury Trauma
Active, Not Recruiting·N/A·Other

A Study to Learn More About The Safety of Diroximel Fumarate (VUMERITY®) in Participants Who Took it During Pregnancy And About the Health of Their Babies

Biogen

Multiple Sclerosis
Active, Not Recruiting·N/A·psilocybin

Measurement of Serum Inflammatory Markers in Patients Treatment-resistant Depression Given Psilocybin

King's College London

Depression - Major Depressive Disorder
Active, Not Recruiting·Phase 2·psilocybin

Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder

Johns Hopkins University

Major Depressive DisorderAlcohol Use Disorder
Active, Not Recruiting·Phase 4·ketamine

Ketamine vs Lidocaine in Traumatic Rib Fractures

Brittany Hoyte

Rib FracturesRib Fracture MultipleRib Trauma
Active, Not Recruiting·Phase 1·DMT

Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans

Yale University

Major Depressive DisorderDepression
Active, Not Recruiting·N/A·DMT

A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Multiple Sclerosis and Their Infants

Bristol-Myers Squibb

Multiple Sclerosis
Active, Not Recruiting·Phase 4·ketamine

Ketamine + Cognitive Training for Suicidality in the Medical Setting

Rebecca Price

Suicide, Attempted
Active, Not Recruiting·Phase 2·psilocybin

An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD)

Sheppard Pratt Health System

Treatment Resistant Depression
Active, Not Recruiting·Phase 2·psilocybin

Pilot Trial of Visual Healing® in Psilocybin-assisted Therapy for Alcohol Use Disorder

Keith Heinzerling

Alcohol Use Disorder
Active, Not Recruiting·Phase 1·ketamine

Glutamatergic Mechanisms of Psychosis and Target Engagement (SA1)

New York State Psychiatric Institute

Healthy
Active, Not Recruiting·N/A·psilocybin

Retrospective Observational Study of Intensity Effects in Psychedelic-assisted Treatment

University Hospital, Geneva

Major Depressive Disorder (MDD)Anxiety DisordersSubstance Use Disorder (SUD)+1 more
Active, Not Recruiting·Phase 3·ketamine

Perioperative Lidocaine and Ketamine in Abdominal Surgery

The Cleveland Clinic

Postoperative Pain
Active, Not Recruiting·Phase 3·DMT

Disease Modifying Therapies Withdrawal in Inactive Secondary Progressive Multiple Sclerosis Patients Older Than 50 Years (STOP-I-SEP)

Rennes University Hospital

Multiple Sclerosis
Active, Not Recruiting·Early Phase 1·ketamine

Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:

Mayo Clinic

Major Depressive DisorderTreatment Resistant DepressionBipolar Depression
Active, Not Recruiting·Phase 1·psilocybin

Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder

Yale University

Major Depressive Disorder
Active, Not Recruiting·Phase 3·Other

Facilitating Rapid Naltrexone Initiation

New York State Psychiatric Institute

Opioid Dependence
Active, Not Recruiting·Phase 3·ketamine

Intranasal Ketamine as an Adjunct to Fentanyl for the Prehospital Treatment of Acute Traumatic Pain

Jason McMullan

Acute Traumatic Pain
Active, Not Recruiting·Phase 2·ketamine

Understanding How Ketamine Brings About Rapid Improvement in OCD

Stanford University

Obsessive-Compulsive Disorder
Active, Not Recruiting·N/A·ketamine

Imaging SV2A in Mood Disorders

Yale University

Major Depressive DisorderPost-Traumatic Stress Disorder
Approved for Marketing·N/A·ketamine

Pre-Approval Access to Esketamine Nasal Spray for the Treatment of Treatment-Resistant Depression (TRD)

Janssen Research & Development, LLC

Depressive Disorder, Treatment-Resistant
Approved for Marketing·N/A·LSD

BMN 110 US Expanded Access Program

BioMarin Pharmaceutical

Mucopolysaccharidosis IVAMorquio A SyndromeMPS IVA
Completed·Phase 4·ketamine

The Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron

Mayo Clinic

Allergy
Completed·Phase 1·MDMA

Comparative Acute Effects of R-MDMA and S-MDMA in Healthy Participants

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 1·psilocybin

A Study Assessing Brain Activity, Safety, Tolerability, and Pharmacokinetics Following Multiple Doses of MLS101 (Psilocybin) in Healthy Volunteers

MycoMedica Life Sciences PBC

Healthy Volunteer
Completed·Early Phase 1·LSD

Drug Effects on Mood and Behavior - Expectancy

University of Chicago

LSD
Completed·N/A·Other

Outcome of Multimodal Anesthesia Bern

Insel Gruppe AG, University Hospital Bern

Opioid UsePain, PostoperativePostoperative Complications+1 more
Completed·Phase 1·ketamine

Combining Esketamine and Prolonged Exposure Treatment for PTSD (Post Traumatic Stress Disorder)

The University of Texas Health Science Center at San Antonio

Post Traumatic Stress Disorder PTSD
Completed·Early Phase 1·LSD

Mood Effects of Serotonin Agonists: Depression

University of Chicago

LSDMajor Depressive DisorderDepression
Completed·N/A·Other

A Real-world Study of Disease-modifying Therapy Treatment Outcomes in Patients With Spinal Muscular Atrophy

Novartis Pharmaceuticals

Muscular Atrophy, Spinal
Completed·Phase 4·ketamine

ESKetamine Low-dose vs Ketamine Low-dose for Severe Acute Pain in Emergency Units, Comparison of PsychodyslEptic Effects

Centre Hospitalier Universitaire de Nice

Acute Pain
Completed·Phase 2·ketamine

Evaluating the Neuromodulatory Effect of Ketamine in Long COVID-19

University of Texas at Austin

Long COVID
Completed·Phase 1·psilocybin

Acute Effects of MDMA Co-administration on the Response to Psilocybin in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·N/A·Other

A Study of Treatment Patterns and Annualized Relapse Rate in Multiple Sclerosis Patients Who Escalate Versus Continue Disease-Modifying Therapies Following Relapse

Novartis Pharmaceuticals

Multiple Sclerosis
Completed·N/A·DMT

Dance Movement Therapy for Radio-oncological Patients

University of Erlangen-Nürnberg Medical School

Cancer Patients and Physical Activity
Completed·Phase 1·ketamine

Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants

University Hospital, Basel, Switzerland

Healthy
Completed·N/A·psilocybin

Evaluation of the Effect of a Single Dose of Psilocybin on Neural Correlates of Cognitive Control in Patients With Psychogenic Nonepileptic Seizures

Centre Hospitalier Universitaire de Nīmes

Psychogenic Nonepileptic SeizuresPsilocybin
Completed·Phase 1·ketamine

KF2024#1-trial: Esketamine Interaction Study

Helsinki University Central Hospital

Drug InteractionsFood-drug Interaction
Completed·Phase 1·psilocybin

A Second Psilocybin Group Therapy for the Treatment of Cancer-Related Anxiety in Partial Responders With Metastatic Cancer

University of Washington

Hematopoietic and Lymphatic System NeoplasmMetastatic Malignant Solid Neoplasm
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.