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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 241288 of 1728 trials
Completed·Early Phase 1·psilocybin

Precision Functional Brain Mapping in Psilocybin

Washington University School of Medicine

Psilocybin
Completed·Phase 1·psilocybin

Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study

Imperial College London

Anorexia Nervosa
Completed·Phase 1·psilocybin

Pilot RECAP Study in Healthy Volunteers

University of Wisconsin, Madison

Psychedelic ExperiencesAmnesia
Completed·N/A·DMT

Discontinuation of Disease Modifying Therapies (DMTs) in Multiple Sclerosis (MS): Extension of the DISCOMS Study

University of Colorado, Denver

Multiple Sclerosis
Completed·Phase 2·psilocybin

Evaluation of Psilocybin in Anorexia Nervosa: Safety and Efficacy

University of California, San Diego

Anorexia Nervosa
Completed·Phase 4·ketamine

Ketamine Versus Fentanyl for Surgical Abortions

University of Washington

Abortion in First TrimesterPain, ProceduralOpioid Use
Completed·Phase 4·ketamine

Effect of Postoperative Single Dose of Ketamine on Pain After Mastectomy

NYU Langone Health

Postoperative Pain
Completed·Phase 4·ketamine

A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray Treatment

Janssen-Cilag Ltd.

Depressive Disorder, Major
Completed·Phase 4·ketamine

An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin in Treatment of Acute Headache

Antonios Likourezos

Pain
Completed·Phase 4·ketamine

A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone for Musculoskeletal Pain

Antonios Likourezos

Pain
Completed·Phase 4·ketamine

The Impact of Perioperative Ketamine Infusion on Surgical Recovery

Vanderbilt University Medical Center

Opioid UseEnhanced Recovery After SurgeryAnesthesia+2 more
Completed·Phase 1·ketamine

Modified Ketogenic Diet and Ketamine for Anorexia Nervosa

Homeostasis Therapeutics, LLC

Anorexia Nervosa
Completed·Phase 1·ibogaine

A Study of Oral Ibogaine in Opioid Withdrawal

atai Therapeutics, Inc.

Opiate Withdrawal Syndrome
Completed·Phase 1·ketamine

Study of CT001 in Healthy Volunteers

Cessatech A/S

Bioavailability
Completed·Phase 2·ketamine

Ketamine-enhanced Prolonged Exposure Therapy in PTSD

VA Office of Research and Development

PTSD
Completed·Phase 3·MDMA

A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSD

Resilient Pharmaceuticals

PTSD
Completed·N/A·ketamine

Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention

Yale University

Depression and Suicide
Completed·N/A·Other

RelieVRx for Total Knee Arthroplasty (TKA) for the Reduction of Acute Postoperative Pain and Opioid Use

AppliedVR Inc.

Opioid UseArthropathy of KneePain, Postoperative
Completed·N/A·MDMA

Long-Term Safety and Effectiveness of MDMA-Assisted Therapy for PTSD

Resilient Pharmaceuticals

PTSD
Completed·Phase 2·psilocybin

Safety and Efficacy of Psilocybin for Body Dysmorphic Disorder

New York State Psychiatric Institute

Body Dysmorphic Disorders
Completed·N/A·Other

Effects of Dimethyl Fumarate on Cognitive Performance and Brain Abnormalities in Multiple Sclerosis.

IRCCS Centro Neurolesi Bonino Pulejo

Multiple Sclerosis
Completed·N/A·MDMA

Circulating Oxytocin Changes in Response to the Oxytocin System Stimulator MDMA in Patients With Diabetes Insipidus and Healthy Controls

University Hospital, Basel, Switzerland

Diabetes Insipidus
Completed·Phase 1·DMT

SPL026 (DMT Fumarate) in Healthy Subjects and MDD Patients

Small Pharma Ltd

Major Depressive Disorder
Completed·N/A·ketamine

Prospective Multicentre Study of the Use of Ketamine in the Treatment of Refractory Chronic Pain in the French CLCC

Centre Leon Berard

CancerChronic PainNeuropathic Pain+1 more
Completed·N/A·ketamine

Exploring Sedation Types During Cataract Surgery

Vance Thompson Vision

Vital Signs
Completed·N/A·ketamine

Pharmacogenetics Associated With IV Ketamine

Brain and Cognition Discovery Foundation

Treatment Resistant Depression
Completed·N/A·ketamine

Ketamine for Pain Control After Severe Traumatic Injury

Medical College of Wisconsin

Hospital Inpatient Trauma InjuryPain Management
Completed·Early Phase 1·ketamine

Inpatient Single Dose Interventions for Alcohol Use Disorder

Denver Health and Hospital Authority

Alcohol Use Disorder, Severe
Completed·N/A·ketamine

Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in Depression

Douglas Mental Health University Institute

Depressive Disorder, Treatment-ResistantDepressive Disorder, MajorUnipolar Depression+1 more
Completed·Phase 1·ketamine

Phase 1 Evaluation of (2R,6R)-Hydroxynorketamine

National Institute of Mental Health (NIMH)

Major Depressive Disorder
Completed·N/A·ketamine

Analgesic Efficacy of Orally Administered VTS-K for Pain Management

Antonios Likourezos

Pain, Acute
Completed·Phase 2·psilocybin

The Effect of Psilocybin on MDD Symptom Severity and Synaptic Density

Section for Affective Disorders; Northern Stockholm Psychiatry

Major Depressive DisorderDepression
Completed·Phase 1·MDMA

Effects of MDMA Co-administration on the Response to LSD in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 2·Other

Cardiac Index and General Anesthesia Without Opioid.

Centre Hospitalier de Montauban

Hip ArthropathyHip Disease
Completed·Phase 2·ketamine

A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of Suicide

Seelos Therapeutics, Inc.

Depressive Disorder, MajorSuicidal
Completed·Phase 2·ketamine

Ketamine for the Treatment of Opioid Use Disorder and Depression

Medical University of South Carolina

DepressionOpioid-use DisorderOpioid Abuse
Completed·Phase 1·ketamine

A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine

Boehringer Ingelheim

Healthy
Completed·Phase 1·ketamine

Relative Bioavailability Study of MELT-100, IV Midazolam, and IV Ketamine

Melt Pharmaceuticals

Procedural Sedation
Completed·Early Phase 1·DMT

Neurodynamics of Prosocial Emotional Processing Following Serotonergic Stimulation With N,N-Dimethyltryptamine (DMT) and Harmine in Healthy Subjects

Psychiatric University Hospital, Zurich

EmotionsMoodCognitive Function 1, Social+1 more
Completed·N/A·Other

Characteristics, Adherence, and Persistence Among Multiple Sclerosis Patients Treated With Disease-Modifying Therapies

Novartis

Multiple Sclerosis
Completed·Phase 3·ketamine

The Ketamine for Acute Postoperative Analgesia (KAPA) Trial

University Health Network, Toronto

Postoperative Pain
Completed·Phase 3·ketamine

Ketamine to Prevent PPD After Cesarean

Washington University School of Medicine

Postpartum Depression
Completed·N/A·Other

Pro-inflammatory Role of Blood Platelets in Critically Ill Patients With Septic Shock.

University Hospital, Bordeaux

Septic Shock
Completed·Phase 4·ketamine

A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant Depression

Janssen Research & Development, LLC

Depressive Disorder, Treatment-Resistant
Completed·Phase 2·ibogaine

Preliminary Efficacy and Safety of Ibogaine in the Treatment of Methadone Detoxification

International Center for Ethnobotanical Education, Research, and Service

Drug DependenceDrug Use DisordersOpioid Dependence
Completed·Phase 4·ketamine

Ketamine for Older Adults Pilot

Washington University School of Medicine

Treatment Resistant DepressionRefractory DepressionTherapy-Resistant Depression+2 more
Completed·Phase 1·LSD

Effect of Ketanserin After LSD Administration

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 4·ketamine

Ketamine Treatment Effects on Synaptic Plasticity in Depression

New York State Psychiatric Institute

Major Depressive Disorder
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.