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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 145192 of 1748 trials
Completed·Phase 1·psilocybin

Psilocybin-assisted CBT for Depression

University of California, Los Angeles

Major Depressive Disorder
Completed·N/A·ketamine

The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric Surgery

Tiva Group

Pharmacological ActionPost Operative PainOpioid Use+2 more
Completed·Phase 2·DMT

A Trial of GH001 in Patients With Treatment-resistant Depression

GH Research Ireland Limited

Treatment-resistant Depression
Completed·N/A·ketamine

Lidocaine and Ketamine Levels in Plasma After Simultaneous Lidocaine/Ketamine Infusions

University Hospital, Basel, Switzerland

Chronic Pain
Completed·Phase 4·Other

Opioid-free Analgesia in Intensive Care Unit

Centre Hospitalier Universitaire de Nīmes

Intubation
Completed·Phase 1·DMT

Dose-finding Study for the Combination of DMT and Harmine in Healthy Subjects

Reconnect Labs

Healthy
Completed·Early Phase 1·ketamine

Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder

Medical University of South Carolina

Tobacco UseSmoking CessationNicotine Dependence
Completed·N/A·ketamine

Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression

Medical University of Gdansk

Treatment-Resistant DepressionMajor Depressive Disorder
Completed·N/A·ketamine

Effect of Ketamine Infusion on BIS Values

University of Padova

Anesthesia Brain MonitoringKetamine
Completed·N/A·ketamine

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

Beth Israel Deaconess Medical Center

Postoperative DeliriumHemodynamic InstabilityPain+1 more
Completed·Early Phase 1·ayahuasca

Mindfulness and Psychedelics

Milan Scheidegger

Healthy Participants
Completed·N/A·DMT

Real-World Persistence and Adherence of Ofatumumab Compared to Self-Injectable and Oral DMTs in Patients With Multiple Sclerosis

Novartis

Multiple Sclerosis
Completed·Early Phase 1·ketamine

The Effects of Sedatives on Tobacco Use Disorder Version 2

Wake Forest University Health Sciences

Tobacco Smoking
Completed·N/A·DMT

The 'Wearing Off' Effect of DMT

Novartis Pharmaceuticals

Multiple Sclerosis
Completed·Phase 1·Other

IM and IV SPL026 Drug Product in Healthy Participants

Small Pharma Ltd

Major Depressive Disorder
Completed·Phase 1·psilocybin

PAPR: PAP + MBSR for Front-line Healthcare Provider COVID-19 Related Burnout

University of Utah

DepressionBurnout, Professional
Completed·Phase 1·DMT

Pharmacokinetics, Safety, and Tolerability of Intramuscular 5-MeO-DMT in Healthy Volunteers

Usona Institute

PharmacokineticsSafetyTolerability
Completed·Phase 1·DMT

Safety and Pharmacokinetics of GH002 in Healthy Volunteers

GH Research Ireland Limited

Healthy Volunteers
Completed·Phase 1·DMT

SPL026 With or Without SSRIs in Participants With MDD

Small Pharma Ltd

Major Depressive Disorder
Completed·N/A·psilocybin

Psilocybin in Adults With and Without Autism Spectrum Disorder

King's College London

Autism Spectrum Disorder
Completed·Phase 4·ketamine

Low Dose Ketamine Infusion for Analgesia in the Emergency Department to Reduce Side Effects

Summa Health System

Pain, AcuteDissociation
Completed·Phase 4·ketamine

Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression

Theresa Jacob, PhD, MPH

Treatment Resistant DepressionMajor Depressive DisorderAnalgesia+10 more
Completed·N/A·Other

Nociception Level During Opioid-sparing Anaesthesia Versus Conventional Opioid-based Anaesthesia

University Hospital, Basel, Switzerland

Analgesia
Completed·Phase 1·DMT

Acute Dose-dependent Effects of DMT in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 1·psilocybin

Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic Pain

Emory University

Hematopoietic and Lymphoid Cell NeoplasmMalignant Solid Neoplasm
Completed·Phase 1·psilocybin

PsilOCD: A Pharmacological-Challenge Feasibility Study

Imperial College London

Obsessive-Compulsive Disorder
Completed·Phase 1·LSD

Effects of SERT Inhibition on the Subjective Response to LSD in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 2·psilocybin

Efficacy and Safety of COMP360 Psilocybin Therapy in Anorexia Nervosa: a Proof-of-concept Study

COMPASS Pathways

Anorexia Nervosa
Completed·Phase 1·psilocybin

Psilocybin-assisted Therapy for Phantom Limb Pain

University of California, San Diego

Phantom Limb Pain
Completed·Phase 3·ketamine

Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents

University of Texas Southwestern Medical Center

Suicide, AttemptedSuicide and DepressionSuicide Threat
Completed·Phase 1·MDMA

Acute Effects of R- and S-MDMA in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 2·ketamine

Efficacy and Pharmacokinetic-Pharmacodynamic Relationship of Intranasally Administered Sufentanil, Ketamine, and CT001

Cessatech A/S

Pain
Completed·Phase 2·LSD

A Dose-Finding Study of MM120 (LSD D-Tartrate) for the Treatment of Anxiety Symptoms

Definium Therapeutics US, Inc.

Anxiety Generalized
Completed·Phase 2·ketamine

Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression

Joshua Rosenblat

Bipolar DisorderBipolar DepressionBipolar I Disorder+1 more
Completed·N/A·MDMA

Perceptions of MDMA-Assisted Therapy Among Veterans With PTSD

Albany Research Institute, Inc.

Post Traumatic Stress Disorder
Completed·Phase 3·ketamine

Ketamine Low dOse Evaluation on Morphine Consumption in Traumatic Patient

Assistance Publique Hopitaux De Marseille

Traumatic Injury
Completed·Phase 1·psilocybin

A Study of a Psilocybin Analog (CYB003) in Healthy Participants With and Without Major Depressive Disorder

Cybin IRL Limited

Major Depressive Disorder
Completed·Phase 3·Other

Chest Wall Block After Sternotomy: Randomized Controlled Trial in Cardiac Surgery: (PABLOS Study)

University Hospital, Angers

Pain, PostoperativeCardiac Surgery
Completed·Phase 1·MDMA

Food Effects on Bioavailability of MDMA in Healthy Volunteers

Resilient Pharmaceuticals

Pharmacokinetics
Completed·Phase 4·ketamine

Anhedonia, Development, and Emotions: Phenotyping and Therapeutics

Erika Forbes

DepressionAnhedonia
Completed·Phase 2·ketamine

Ketamine for Treatment-Resistant Bipolar Disorder

Joshua Rosenblat

Bipolar DisorderBipolar DepressionBipolar I Disorder+1 more
Completed·Phase 1·psilocybin

Effects of Psilocybin in Post-Treatment Lyme Disease

Johns Hopkins University

Post-Treatment Lyme DiseaseChronic Lyme DiseaseLyme Disease, Chronic
Completed·Phase 1·psilocybin

An Evaluation of Psilocybin's Effect on Cardiac Repolarization and the Effect of Food on Psilocybin's Pharmacokinetics

Usona Institute

QTc IntervalPharmacokinetics
Completed·Phase 2·Other

Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)

University of Utah

Hypoxic-Ischemic EncephalopathyPain
Completed·Phase 2·psilocybin

The Safety and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder

COMPASS Pathways

Post Traumatic Stress Disorder
Completed·N/A·Other

Comparison of Two Magnesium Sulfate Protocols in Opioid-Free Anesthesia for Bariatric Surgery

Hospital HM Nou Delfos

Postoperative PainObesityBariatric Surgery+1 more
Completed·Phase 1·ketamine

Investigation of Intranasal Ketamine Related Changes in Attentional Brain Networks With Functional and Structural MRI

Rupert Lanzenberger

Ketamine Treatment
Completed·N/A·Other

OFA vs OBA in Bariatric Surgery

Hospital HM Nou Delfos

ObesityPostoperative PainBariatric Surgery+1 more
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.