Not Yet RecruitingN/Aketamine
Esketamine Versus Sufentanil for Sedation in Patients Undergoing ERCP
Sponsored by Ren Da
NCT ID
NCT07702240
Target Enrollment
530 participants
Start Date
2026-07-10
Est. Completion
2028-03-10
About This Study
This study compares two anesthesia medications, esketamine and sufentanil, used together with propofol during ERCP procedures. The goal is to find out which combination provides better safety and comfort for people undergoing ERCP. Participants will be randomly assigned to receive either esketamine or sufentanil during sedation. Researchers will monitor blood oxygen levels, blood pressure, and recovery time during and after the procedure to evaluate safety and effectiveness.
Conditions Studied
Interventions
- •Esketamine
- •Sufentanil
Eligibility
Age:18 Years - 90 Years
Healthy Volunteers:No
View full eligibility criteria
Inclusion Criteria: * Adults aged ≥18 years * Patients scheduled to undergo endoscopic retrograde cholangiopancreatography (ERCP) * American Society of Anesthesiologists (ASA) physical status I-III * Body mass index (BMI) between 18.5 and 30 kg/m² * Patients requiring sedation for ERCP * Ability to provide written informed consent voluntarily Exclusion Criteria: * Allergy or contraindication to propofol, esketamine, sufentanil, or related medications * Severe hypertension (systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg) * Severe dysfunction of the heart, lungs, liver, or kidneys * History of central nervous system disorders or psychiatric disorders * Anticipated difficult airway * History of psychiatric disorders or contraindications to ketamine use * Inability to communicate or provide informed consent * Requirement for general anesthesia with endotracheal intubation or intraoperative conversion to general anesthesia with intubation