Pilot Randomized Control Trial Comparing Oral Ketamine and Oral Oxycodone for Pain Control in Emergency Department Patients

About This Study

The goal of this pilot randomized clinical trial is to learn if oral ketamine intervention can control pain in emergency department patients whose providers feel the need for additional pain medication. The main questions it aims to answer are: * Does oral ketamine result in a different mean change in pain scores compared with oral oxycodone? * Is there a difference in the need for additional opioid administration within 24 hours after the initial dose of study medication (oral ketamine vs oral oxycodone)? Researchers will compare oral ketamine to oral oxycodone to see if there is a difference in pain control or the need for additional opioid administration. Participants will: * Fill out a survey prior to study medication administration assessing pain scores, pain presentation, and medication history * Be randomized to and receive a dose of oral ketamine or oral oxycodone as the study medication for pain control * Fill out a survey assessing pain control, side effects, and safety outcomes * Receive follow-up phone calls at 1 and 3 months after enrollment to assess pain and opioid use

Conditions Studied

Interventions

• •oral ketamine
• •oxycodone

Eligibility

Inclusion Criteria:

* ED patient aged 18 years or older AND
* English proficient AND
* Able to give informed consent AND
* Has a painful condition in the ED that includes any of the following: Musculoskeletal extremity pain, Musculoskeletal back or neck pain, Other nociceptive extremity pain
* AND treating provider has deemed the patient necessitating 'second line pain therapy' (meaning: opioids or ketamine)

Exclusion Criteria:

Any of the following:

* Prisoner status
* Pregnant
* Non-English proficient
* Cannot give informed consent
* Requires emergent intravenous pain medicine (as deemed by the treating provider)
* Prior participation in the study
* Previous diagnosis of opioid use disorder
* Previous ketamine addiction
* Patient is in hospice or other palliative care measures
* Contraindication to ketamine, including: Cystitis or bladder pain, Intracranial hypertension, Known coronary artery disease, Age greater than 75 years old, History of prior adverse reaction to ketamine or oxycodone, History or current major psychiatric disorder (as deemed by the treating ED clinician) or history of psychosis

Study Locations (1)