Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and Symptoms of Depression

Inclusion Criteria:

1. Healthcare clinicians (physicians, nurses, nurse practitioners, physician assistants) currently in clinical practice
2. Age 25-70 years
3. Loss of meaning single question "I used to find deep meaning in my work as a healthcare clinician, but during the past 5 years that sense of meaning has faded".
4. PHQ-9 score ≥10 (moderate symptoms of depression)
5. Ability to commit to all preparation sessions and retreat attendance
6. English fluency sufficient for group participation
7. Screening laboratory tests within acceptable limits, including liver function tests
8. Negative urine drug screen for non-prescribed psychoactive medications.
9. ECG with QTc \<450 ms
10. Willing to taper and discontinue any supplements with serotonin-like properties, including but not limited to 5-HTP, St. John's Wort, and 'brain food' supplements.
11. For participants of childbearing potential, agree to use to use highly effective contraception. Highly effective contraceptive methods are defined as those that, alone or in combination, result in a low failure rate (less than 1 percent per year), including but not limited to implants, IUDs, contraceptive injections, or contraceptive pills.

Exclusion Criteria:

1. Personal or first-degree family history of psychotic disorder or bipolar I disorder
2. Personal major depressive episode prior to entering healthcare as a professional
3. Active suicidal ideation with intent or plan
4. Unstable medical conditions
5. Pregnancy or breastfeeding
6. Hypertension with BP systolic \>150 or diastolic \> 90